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| 基于“关格-疳积”理论畲药验方承气汤协同内镜介入治疗恶性肠梗阻的临床研究 |
| Clinical Study of She Ethnic Medicine Chengqi Decoction Synergized with Endoscopic Intervention in the Treatment of Malignant Bowel Obstruction Based on the Theory of |
| 投稿时间：2026-03-20 修订日期：2026-03-20 |
| 中文关键词: 关格 疳积 畲药验方承气汤 恶性肠梗阻 内镜介入 中西医结合 |
| 英文关键词: Guange Ganji She Ethnic Medicine Chengqi Decoction Malignant bowel obstruction Endoscopic intervention Integrated traditional Chinese and Western medicine |
| 基金项目:浙江省自然科学基金联合基金/探索项目(LKLY26H030003)；浙江省卫生健康行业科技计划项目(2025HY1579) |
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| 中文摘要: |
| 目的 基于中医“关格”理论与畲医“疳积”理论的融合创新,评估畲药验方承气汤协同内镜介入治疗恶性肠梗阻(malignant bowel obstruction,MBO)的临床疗效。方法 选取2021年4月至2025年6月丽水市中医院收治的54例MBO患者作为研究对象,采用随机数字表法分为研究组(n=28)与对照组(n=26)。对照组患者接受内镜下肠道金属支架置入术加常规治疗,研究组患者在此基础上术后24h加服畲药验方承气汤。比较两组患者的临床症状改善、症状缓解时间、功能状态、生活质量、总体疗效、住院时间及“关格”危象发生率等情况。结果 两组患者基线资料比较差异无统计学意义(P>0.05)。研究组患者在第3天和第7天的腹胀腹痛、恶心呕吐、排气排便等临床症状改善评分均优于对照组(P<0.05)。研究组患者的症状缓解时间显著缩短,卡氏功能状态评分及生活质量评分均高于对照组(P<0.05)。研究组患者的临床总有效率为96.4%,高于对照组的80.8%(P<0.05)。研究组住院时间显著短于对照组(P<0.05)。研究组“关格”危象发生率(3.6%)显著低于对照组(15.4%)(P<0.05)。结论 基于“关格-疳积”理论的畲药验方承气汤协同内镜介入治疗可有效缓解MBO患者的临床症状,阻断“关格”危象发生,缩短住院时间,安全性良好,体现了“破格攻积”协同治疗新模式的优势。 |
| 英文摘要: |
| Objective Based on the integrated innovation of Traditional Chinese Medicine "Guange" theory and She Ethnic Medicine "Ganji" theory, to evaluate the clinical efficacy of She Ethnic Medicine Formula Chengqi Decoction synergized with endoscopic intervention in the treatment of malignant bowel obstruction (MBO). Methods A total of 54 MBO patients admitted to Lishui Hospital of Traditional Chinese Medicine from April 2021 to June 2025 were selected as the research objects. They were divided into study group (n=28) and control group (n=26) by random number table method. The control group received endoscopic intestinal metal stent placement plus conventional treatment, while the patients in the study group were additionally administered She Ethnic Medicine Chengqi Decoction within 24 hours after operation. The clinical outcomes of symptom improvement, symptom remission duration, functional status, quality of life, overall efficacy, hospitalization duration, and incidence of "Guange" crisis were compared between the two groups. Results There was no statistically significant difference in baseline data between the two groups (P>0.05). Abdominal distension, pain, nausea, vomiting, flatulence, and defecation showed significantly better clinical symptom improvement scores in the study group than the control group on day 3 and 7 (P<0.05). The study group also demonstrated significantly shorter symptom relief duration, with higher Karnofsky function scores and quality of life scores (P<0.05). The overall clinical response rate in the study group was 96.4%, compared to 80.8% in the control group (P<0.05). The hospitalization time in the study group was significantly shorter than that in the control group (P<0.05). The incidence of "Guange" crisis in the study group (3.6%) was significantly lower than that in the control group (15.4%) (P<0.05). Conclusion She Ethnic Medicine Chengqi Decoction synergized with endoscopic intervention based on the theory of "Guange" and "Ganji" can effectively relieve the clinical symptoms of MBO patients, prevent the occurrence of "Guange" crisis, shorten the hospitalization time, and has good safety, reflecting the advantages of the new collaborative treatment model of "Poge Gongji". |
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