| Objective: To evaluate the clinical efficacy of Linggui Zhugan Decoction combined with Liujunzi Decoction, based on the theory of "Frequent Yang Deficiency and Frequent Dampness Excess," in treating cough due to Yang deficiency and dampness obstruction pattern in the late stage of wind-warm lung heat disease.Methods: A total of 118 patients with cough of Yang deficiency and dampness obstruction pattern in the late stage of wind-warm lung heat disease, admitted to our hospital between July 2023 and December 2024, were selected and randomly divided into two groups (59 cases each). The control group received compound methoxyphenamine hydrochloride capsules, while the observation group received the same western medicine plus the combination of Linggui Zhugan Decoction and Liujunzi Decoction. The traditional Chinese medicine (TCM) symptom scores, cough scores, inflammatory markers (Interleukin-6 [IL-6], Tumor Necrosis Factor-alpha [TNF-α], C-reactive protein [CRP]), pulmonary function indices, and overall clinical effectiveness were compared between the two groups.
Results: After treatment, the observation group showed significantly greater reductions in TCM symptom scores (primary/secondary/total),cough scores (daytime/nocturnal/total), and levels of inflammatory markers (IL-6, TNF-α, CRP) compared to the control group (P<0.05). The improvement in pulmonary function indices was also significantly greater in the observation group than in the control group (P<0.05). The total clinical effective rate was 94.92% in the observation group, significantly higher than the 76.27% in the control group (P<0.05).Conclusion: The combination of Linggui Zhugan Decoction and Liujunzi Decoction demonstrates significant clinical efficacy in treating cough of Yang deficiency and dampness obstruction pattern in the late stage of wind-warm lung heat disease. It is superior to western medicine alone in alleviating symptoms and signs, improving inflammatory markers, and enhancing pulmonary function. |
