|
| 铁死亡调控新视角：姜黄素的双重效应 |
| A new perspective on ferroptosis regulation: the dual effects of curcumin |
| 投稿时间：2025-06-05 修订日期：2025-06-05 |
| 中文关键词: 姜黄素 癌 组织损伤 铁死亡 |
| 英文关键词: . curcumin cancer tissue injuries ferroptosis |
| 基金项目:国家自然科学基金（82004333），浙江省自然科学基金（LQ21H290002），浙江省中医药科技计划（2022ZA044、2023ZR005） |
|
| 摘要点击次数: 50 |
| 全文下载次数: 0 |
| 中文摘要: |
| 铁死亡是近年来发现的一种细胞死亡形式,其特征是铁累积和脂质过氧化。与细胞凋亡、坏死和自噬不同,铁死亡通过一种独特的分子途径发挥作用。姜黄素是一种源自姜黄根茎的天然活性成分,具有广泛的生物活性与治疗潜力,涵盖神经保护、抗代谢综合征、抗炎及抗癌等多个方面。越来越多证据表明,姜黄素具备促氧化和抗氧化双重特性,会因细胞类型的差异而有所不同。本综述旨在综合当前研究成果,深入剖析姜黄素在铁死亡信号传导机制中的作用：姜黄素可诱导癌细胞发生铁死亡,而在组织损伤场景下则抑制铁死亡的发生。尽管如此,仍需进一步研究来阐明姜黄素对疾病治疗的重要作用。 |
| 英文摘要: |
| Ferroptosis is a recently identified form of cell death characterized by iron accumulation and lipid peroxidation. Unlike apoptosis, necrosis, and autophagy, ferroptosis operates through a unique molecular pathway. Curcumin, derived from turmeric rhizomes, is a natural compound with a variety of biological activities and therapeutic benefits, including neuroprotective, anti-metabolicsyndrome, anti-inflammatory, and anti-cancer properties. Increasing evidence suggests that curcumin possesses both pro-oxidant and antioxidant properties, which can vary depending on the cell type. In this review, we explore the effects of curcumin underlying the ferroptosis signaling pathway, drawing from current in vivo and in vitro research. Curcumin has been found to induce ferroptosis in cancer cells while acting as an inhibitor of ferroptosis in tissue injuries. Nonetheless, further research is needed to clarify the important role of curcumin in advancing disease treatment. |
|
View Fulltext
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
