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| 崔云教授应用六味地黄汤类方治疗少弱精子症经验 |
| Experience of Professor CUI Yun in Treating Oligoasthenospermia with Liuwei Dihuang Decoction and Its Modified Prescriptions |
| 投稿时间：2025-04-19 修订日期：2025-04-19 |
| 中文关键词: 男性不育症 少弱精子症 六味地黄汤 异病同治 数据挖掘 名医经验 |
| 英文关键词: Male Infertility Idiopathic o1igoasthenospermia Liuwei Dihuang Tang Treating Different Diseases with the Same Therapy Data Mining Experience of Renowned Physicians |
| 基金项目:浙江省中医药科技计划项目 |
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| 中文摘要: |
| 目的 研究崔云教授应用六味地黄汤化裁方治疗少弱精子症的用药规律和指导思想。方法 选取崔师门诊治疗少弱精子症处方200首,建立用药数据库,采用频数分析、关联规则分析、聚类分析对药物配伍规律进行数据挖掘。结果 200首处方涉及97味药,使用频次2563次。使用频次超过10次的中药有39味,药物累积频率达90.11%,前六位依次为茯苓、生地、山茱萸、牡丹皮、泽泻、山药。前四位化裁方依次为参芪地黄汤、归芍地黄汤、麦味地黄汤、归芪地黄汤。关联规则分析得出各化裁方常用药物组合,如归芍地黄汤常用蝉蜕多配伍荆芥、乌梅或防风,归芪地黄汤常与豨莶草配伍五味子、升麻或连翘等同用。高频药物聚类分析得到7个聚类方,集中反映崔师治疗少弱精子症以肝肾为中心围绕五脏进行脏腑辨治,以瘀( 血瘀、精瘀) 、痰、湿、热、风、毒为重点的病因辨治。结论 崔师治疗少弱精子症谨守病机,用药以六味地黄汤化裁方滋补肝肾,清化湿热为主,兼顾健脾、养心、活血、理气、解毒等,契合病机; 总的用药特点可概括为清补兼施,虚实兼顾,动静相合。 |
| 英文摘要: |
| Objective: To study the medication rules and guiding ideology of Professor Cui Yun in treating idiopathic o1igoasthenospermia(IOA)with modified Liuwei Dihuang Decoction.Methods: 200 prescriptions for treating oligoasthenospermia from Professor Cui"s outpatient clinic were selected. A medication database was established, and frequency analysis, association rule analysis, and cluster analysis were used to conduct data mining on the drug compatibility rules.Results: The 200 prescriptions involved 97 kinds of herbs, with a total frequency of 2563 times. There were 39 traditional Chinese medicines with a frequency of more than 10 times, and the cumulative frequency of these drugs reached 90.11%. The top six were Poria cocos, Rehmannia glutinosa, Cornus officinalis, Paeonia suffruticosa, Alisma orientale, and Dioscorea opposita. The top four modified prescriptions were Shenqi Dihuang Decoction, Guishao Dihuang Decoction, Maiwei Dihuang Decoction, and Guiqi Dihuang Decoction. Through association rule analysis, the common drug combinations of each modified prescription were obtained. For example, in Guishao Dihuang Decoction, Cicada Slough was often combined with Schizonepeta tenuifolia, Dark Plum, or Saposhnikovia divaricata. In Guiqi Dihuang Decoction, Siegesbeckia orientalis was often used together with Schisandra chinensis, Cimicifuga foetida, or Forsythia suspensa. Cluster analysis of high - frequency drugs obtained 7 clustered prescriptions, which centrally reflected that Professor Cui"s treatment of oligoasthenospermia centered around the liver and kidney, carried out viscera differentiation and treatment around the five zang - organs, and focused on the etiological differentiation and treatment of stasis (blood stasis and sperm stasis), phlegm, dampness, heat, wind, and toxin.Conclusion: Professor Cui adheres to the pathogenesis in the treatment of oligoasthenospermia, treats different diseases with the same method. The medications mainly use modified Liuwei Dihuang Decoction to nourish the liver and kidney and clear away damp - heat, and also take into account invigorating the spleen, nourishing the heart, promoting blood circulation, regulating qi, and detoxifying, which is in line with the pathogenesis. The overall medication characteristics can be summarized as the combination of clearing and tonifying, considering both deficiency and excess, and the combination of movement and stillness. |
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